Introduction course to Population PK and PK/PD modelling with NONMEM 2020



During this three days course, participants will be introduced  to the basic principles of population approach nonlinear mixed effects modelling in pharmacokinetic (PK) and pharmacodynamic (PD) evaluation of drugs and will have opportunities for hands-on PK and PK/PD modelling and simulation examples relevant to drug development. Topics include how to work with NONMEM and R, data file preparation, model coding and visualization/interpretation of the results.

Target audience
The course is intended for people who have a basic knowledge of PK, PD and data analysis, and wish to extend their knowledge and skills on PK/PD in drug development.

Course objectives
Aim of the course is to familiarize the participants with the basics of population PK/PD modelling and to train the participants in working with NONMEM to conduct population PK and PK/PD data analyses.


  • Instructor Dr. Jasper Stevens
  • Duration 3 x 8 hours
  • Dates 6, 7 and 8 May 2020; 09:00-17:00
  • Location University Medical Center Groningen, The Netherlands
  • Language English
  • Maximum capacity 16 participants

Course overview

  • Session 1 Introduction to population PK modelling, NONMEM and R
  • Session 2 NONMEM work flow for population PK models; data management, data exploration, model code and execution, output and interpretation
  • Session 3 Population PK models continued: alternative administration routes, solving differential equations using NONMEM and simulations
  • Session 4 Population PK/PD models: introduction to PK/PD models and implementation of direct effect models in NONMEM
  • Session 5 Population PK/PD models: effect compartment and indirect response models





Course fee
The course fee is 1200 EUR, including course materials, coffee breaks, lunches and one evening dinner (Wednesday evening). Computers are available, including the required software packages. A limited number of (PhD) students can register for a reduced fee (600 EUR), for which a support
letter of the supervisor has to be included upon registration.
Cancellation received before April 10th, 2020 is subject to full refund, cancellation received after this date is subject to 50% refund.

Informatie & inschrijving

To register for the course, please fill out this form and send it by email to thereby including your name, affiliation and postal address

Evt. overige informatie (documenten en relevante links)

Kent de principes om op basis van bloedconcentratiebepalingen bij een set individuen PK parameters berekenen.

Type: Farmacotherapie

Subtype: Individuele patiëntenzorg

Kent de principes om op basis van populatie gegevens PK-PD analyses verrichten.

Type: Farmacotherapie

Subtype: Individuele patiëntenzorg